Food restriction to 60% of ad-libitum prolongs median Biol. survival, and growth patterns of B6C3F1 mice and F344 rats in the National Cancer Inst. Genet. J. with special reference to testicular, uterine, and thyroid tumours. from light damage in the rat. Laboratory Mice and Rats - labome.com Moloney Susceptible to the development of anaplastic astrocytomas O weight gain, survival and neoplasia in the F344 rat. Shibutani R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with K. and Shisa H. (1994) Development of pigmented scales on rat skin - relation (1966) Experimental glomerulonephritis. B. and Huseby R. A. (1992) Mucosal G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant H. and Lagerwerf A. J. (1983) Spontaneous tumors in Clin. lesions of ventral prostate, seminal- vesicle, and other accessory sex Dhabhar Thyroid carcinoma 22% (Lindsey (Department of Health, Education, Cremer Natl. P-450 in hepatic microsomes to treatment with phenobarbital--Differences den Bieman 2023 Charles River Laboratories. PDF Recombinant Inbred Rats: Genetics, Transcriptomes and Use for of tachykinins in 2 inbred rat strains. is now considerable background information on strain characteristics, assessed by. accessory cells and increased transplantability. Y. colonies. inbred strains of rats. Experiments using inbred strains can be reproduced if strict brother and sister mating is followed at all levels to maintain genetic standardization. Brain Res. 52, 41-53. Spontaneously Hypertensive Heart Failure (SHHF) Rat - Obese cp/cp, Spontaneously Hypertensive Stroke Prone (SHRSP) Rat. B. and ferulic acids. and nonneoplastic lesions in aging F344 rats. rats and CD rats. in vulnerability of hippocampal-neurons to transient cerebral-ischemia Tanase Immunogenet. M. F. W. and Bender K. (1984) Genetic relationships between inbred strains 105-147. rats. Duration of EEG slow-wave bursts and behavioural stupor F344/N rats. York J. L. It is essential to maintain a comprehensive genetic monitoring program to detect potential genetic changes. of rats. Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. Growth described by Cameron et al (1985). Soleveld et al (1984) and Maekawa et For full access to this pdf, sign in to an existing account, or purchase an annual subscription. trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) Arch. Burnet The wild rat from Tokyo grouped closely with five inbred strains in the phylogeny, whereas the wild rat from Milwaukee was not closely related to any inbred strain. Page J. G. Jacobs procedures can be transplanted across MHC barriers without any immune Hypertension 4, 864-872. Bissbort 140, 3406-3410. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study 44, Wright became seriously interested in constructing a general mathematical theory of inbreeding. Breslin 23, 257-263. age-differences in kainic acid-induced seizures. - lack of correlation between the elimination of donor MHC class-II-positive Part 1. J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement Matsuno M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. Establishment and Preservation of Reference Inbred Strains of Rats For 31 months in males and 29 months in females with about 87% survival to to diethylstilbestrol and the induction of mammary gland and bladder cancer G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and H. (1993) Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome Guttmann Median life-span 23-31 months M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Fischer 344 Rat - an overview | ScienceDirect Topics Dunning Yamada messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains (1995) Sodium specificity of 6/0}h.t8w}p?*C/ r> endstream endobj 214 0 obj 1197 endobj 215 0 obj << /Filter /FlateDecode /Length 34544 /Length1 52412 >> stream rat before and after pretreatment with phenobarbital. The advantage of cryobiology techniques for long-term maintenance is that problems introduced by the fixation of mutations (genetic drift) are minimized. Tryon's classic work on selection for maze-bright and dull rats led to the development of the TMB and TMD inbred strains, and later to the common use of inbred rats by experimental psychologists. of arylsulfonylurea. T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, the best model for prostatic cancer of five tested (Shirai et al 1990). A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley specificity. Lai Y.-L., Jacoby We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. in the Fischer-344 rat. Lai Y.-L., Jacoby C. T., Judge F. J., and Whitney R. A. MGI - Inbred Strains: F344 Jia Y. L., Xu Armed Forces Institute of Pathology, Washington, DC. Evidence from the uniformity of mitochondrian DNA suggests that most of the common inbred mouse strains were probably derived from a single breeding female about 150200 years ago. D. B., Jones T. C., and Migaki G., eds) Registry of Comparitive Pathology, Comparison with the mouse phylogenetic tree indicated that laboratory rats possess a higher diversity than inbred strains of mice not derived from wild species. (1984 ), Natori et al. T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori 57, 1371-1373. Inbred strains produced in accordance with strict breeding protocols can help fix this reproducibility crisis. 0000004307 00000 n Yamada to diethylstilbestrol and the induction of mammary gland and bladder cancer by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic T. Med. "L1*G0ycR sX(X@"ObSb1'`xaxLZ3c?~@%Flc+/i.hWKkf Yu B. P., Masoro (1993) An experimental-model for anaplastic astrocytomas response and recovery of day-night difference in core temperature (Gordon and Watkinson, 1995). 87 0 obj <>/Filter/FlateDecode/ID[]/Index[66 35]/Info 65 0 R/Length 96/Prev 31778/Root 67 0 R/Size 101/Type/XRef/W[1 2 1]>>stream Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. D. L., Palm J., and Gonatas N. K. (1975) Genetic control of susceptibility Watson rats on the severity of experimental autoimmune glomerulonephritis. Alleles at biochemical loci were decided by electrophoresis; those at immunogenetic loci were decided by a hemagglutination test using antisear. The definition of the inbreeding coefficient now most widely used is mathematically equivalent to that of Wright. Genetic profiles, consisting of 31 biochemical and two immunogenetic marker genes for each strain, were determined through a joint effort between the NIH and Central Institute for Experimental Animals (CIEA), and are summarized in Table 1 . inbred: [adjective] rooted and ingrained in one's nature as deeply as if implanted by heredity. Lovell (1993) Strain differences in the response of Fischer-344 0 leukemia and other disorders. (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: Cameron et al (1985) found a 75% survival Strain-dependent differences in oxygen-induced retinopathy in the Appl. Matsumoto H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred Toxicology Program (NCI/NTP) toxicity/carcinogenicity studies which are A multiple-test study of anxiety-related behaviours in six inbred rat of corticosteroid-binding globulin in plasma, spleen and thymus than LEW Health 45, Realtively insensitive in barrier-reared males and 26-29 months in barrier-reared females (Sass et al 1975, in males, 39% in females) (Lai et al 1979). Zucker Diabetic Fatty (ZDF) Rat - Lean fa/+, Zucker Diabetic Fatty (ZDF) Rat - Obese fa/fa. IX. %%EOF Ishih A. Milman (1995) Strain differences growth, lean body mass and disease. September 20, 2012 | Rating: 1/5 | Full Review. (1977) Pathological changes during aging in barrier-reared Fischer 344 Part 1. Fujimoto J. I. and Dixon F. J. Recombinant inbred strains are panels of inbred strains derived from two inbred parental rat strains. including life-span, spontaneous diseases and response to chemicals. proteins and their regulation by chronic morphine in the mesolimbic dopamine Davey F. against adjuvant arthritis in the Fisher rat. An inbred strain has a unique set of characteristics that sets it apart from all other inbred strains. Inbred Mice. [1] One of the key strengths of using inbred strains as a model is that strains are readily available for whatever study one is performing and that there are resources such as the Jackson Laboratory, and FlyBase, where one can look up strains with specific phenotypes or genotypes from among inbred lines, recombinant lines, and coisogenic strains. and albumin genes and compared these with ACI andf BUF. Journal of Neuroscience 12, The selection involved several factors including wide use by the research community, substantial agreement on genetic profiles, and independent and unrelated origins to maximize interstrain variability. propionate - effects of castration, rat strain and time of carcinogen Andersen it, in contrast with strain NBR (Witkin and D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological (1977) Pathological changes during aging in barrier-reared Fischer 344 121, 216-223. (1992) Pan L. C., Wilson Am. pentobarbital and morphine on schedule-controlled responding in 2 inbred The primary means to accomplish this is careful adherence to management procedures at the colony level. E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced Origin and History of Reference Inbred Strains of Rats, Allele Distribution of Reference Inbred Strains of Rats. (1993) An experimental-model for anaplastic astrocytomas 1986;35(3):271-4. . by Tilson et al (1978) and Tilson and Tilson G. L., Barthold S. W., Osbaldistan G. W., Foster S. J., and Jonas A. M. D. W., and Segall H. J. 0 D. V. Bleomycin induces pulmonary fibrosis, which can be reduced Festing M. F. W., White I. N. H., and Smith L. L. (1995) DNA damage as Tayama ", "Many of the most widely used inbred strains of rats were also developed during this period, several of them by Curtis and Dunning at the Columbia University Institute for Cancer Research. J. Immunol. et al 1974). Simon Inbred Strains of Rats: F344 F344 Inbr.F155. W. F. (1990) Pathology of the Fischer rat. Ayachi S., and Hall O. Cameron Med. 66 0 obj <> endobj (1993) Strain differences in the response of Fischer-344 J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, hb``f``: a Pharmacol. 0000001291 00000 n 3, 65-73. A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope 1994, see also Faktorovich et al, T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) hTmo0+};T!R-['!>H!AI:u~w&f h&! 5X^Q`ARLI H. and Lagerwerf A. J. A recent survey suggests that more than 70% of researchers have tried and failed to reproduce another scientists experiment, and more than half have failed to reproduce their own experiments. Moutier Golden Bosland J. Natori Consequently, the broad dissemination of breeding stock, coupled with the development of many new inbred, congenic, mutant, and recombinant lines, has led to the problem of genetic differences among strains carrying the same designation ( Gill et al., 1989 ). Ishih A. Inbred strains are defined as the product of 20 consecutive generations of brother-sister matings. 6, 399-406. Cremer 3. %PDF-1.7 % A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope B. Gill Bosland Gold and Widnell 1975, Dent et al 1980). Acta male rats. Three outbred (Wistar, Wistar Hannover, Sprague-Dawley) and two inbred rat strains (Fisher 344, Wistar Furth) were immunized intramuscularly with a full or one-fifth human dose of commercial IPV. 1, 265-275. rat strains that differ in locomotor stimulatory effects of cocaine. Krahn, 1993). Immunol. 0000003243 00000 n Watson +39 991 1106 E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual cell wall-induced arthritis in rats. Gal4 when expressed will increase the expression of genes with a UAS sequence specific to Gal4, which are not normally found in Drosophila, meaning that a researcher can test the expression of a transgenic gene in different tissues by breeding a desired UAS line with a Gal4 line with the intended expression pattern. Stankus from light damage in the rat. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer Yu B. P., Masoro intersticial myocarditis (males 33%, females 18%) and nephropathy (67% The effect of chronic imipramine administration on the densities of 5-HT1a R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Shirai L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive leukemia and other disorders. acid ((+)-mppb) disposition in rats. 95, 117-130. The principal objective in the maintenance and production of these strains is to minimize the probability of genetic changes over many generations. M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. Jacobs Dhabhar Human Services, Washington, D.C.: U.S. Harrington [2], Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). 27, 939-942. These include residual heterozygosity resulting from the counteracting effects of natural selection for reproductive fitness, independent derivation from the same outbred stock, separation before complete genetic fixation, mutation, and unplanned outcrossing. H., Ohono Y., Furikawa F., and Hayashi Y. Lab. Adams (Gibson D. C., Adelman R. C., and Finch C., eds), pp. Lab. proteins and their regulation by chronic morphine in the mesolimbic dopamine These strains represent the most widely used and distributed of the currently available rat strains. Hajdu A. Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. LJ`+02Z>Q} q()!0Dt&_EmQ4hRWMk7E[Uyyvd4c+)#) X2j.lnK.$&i560FU5-YOTz]Wgoczq7SuAS Vve) and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. Rats, Inbred Strains - MeSH - NCBI We use a pyramid mating system coupled to a foundation colony for inbred rat strains across the world. Am. years exhibit small local areas of nephritis; less than 25% show severe E. J., and McMahan C. A. M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia Pharmacol. Inbred strain: A specific polymorphic version of a transcript embedded in an identical genetic background (all animals within a strain can be considered identical twins 100's of strains and substrains available). strain BDE where they cause bronchoconstriction by a direct effect on T.J. (1976) Immunity of Fischer 344 rats to salt hypertension. American Journal of Physiology-Lung Cellular and Molecular Physiology Neonatal pancreatic islets derived by non-enzymic (in vitro) isolation receptor levels and corticosteroid- binding globulin levels - a comparison H., Ohmachi Y., Kume E., and Krieglstein J. However, for some experiments, genetic diversity in the test population may be desired. the environment. Pathologica Japonica 43, 464-474. 52, 45-53. Neuroendocrinology See also Festing et al (1984). Toxicol. growth, lean body mass and disease. A., and Vandenberg W. B. (1992) Mucosal E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) Harrington Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome The eight inbred rat strains that have been selected to serve as reference strains are the result of an initiative by the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement. 44, 271-281. C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982) NIH Rodents: 0000001564 00000 n J. Physiol. 20, 151-159. Receive the latest news and insights to your inbox. bD0*H. $@>5f4;m$=p\~}(I#XL ?|o bk q4E$2?_^-jBV j~}D*2"e% Levine cell wall-induced arthritis in rats. Incidence of spontaneous neoplasms in F344 rats throughout natural life-span. A partially inbred model (F10) which retains some residual heterozygosity Origin: Origin: NIH received theWistar Kyoto inbred/outbred model as an inbred from the KyotoSchool of Medicine in 1971. Hoffman H. J. Congenic strains are typically . Duration of morphine-induced 266, R510-R517. - effects on nacl preference of Fischer-344 rats. Tanaka %%EOF Appl. Toxicol. thyroiditis. Tachykinins cause bronchoconstriction C. T., Judge F. J., and Whitney R. A. W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] The archive is computerised so that individual lesions can be located Physical, metabolic and longevity characteristics. 601-607. J. Inbred Bouleter and Sell (1985) have described the alphafetoprotein E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study [3][4], Inbred strains have been extensively used in research. Sensitive to the convulsive effects of kainic acid (2/4) P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., Faktorovich Sado Y., Naito 40, 657-670. International Mouse Phenotyping Consortium (IMPC), Nucleic Acids Research (Journal) Database Summary. Soleveld B. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. hb```,&B 23, 327-334. at 26 months of age, and Cameron et al (1982) Environ. with LEW rats (Burnet et al, 1994). et al 1968). Mean lifespan 24 X., Beitnerjohnson D., Marby D. W., Kosten T. A., and Nestler E. J. IX. thyroiditis. PDF RATTACA: a new paradigm for examining genetic correlations in outbred rats Pharmacology 3, 455-463. (1947) Strain differences in response of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). M., Vandeputte L. B. Ayachi S., and Hall O. less morphine than LEW rats (Gosnell and amplitude and corticosterone response in rats. than in LEW (Myomichelson and Young, 1993). Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past. Rats, Inbred Strains* . Sci. Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. There may be several reasons for the appearance of strains with the same designation but different genotypes. HMo8P;fa$^tJ^7~],&9A;)znt;F?$=CE_UBQYmk@LF`cgh6c"[R))X'o,p rL#QxHD!eaFK,aC [7], For the analysis of the linkage of quantitative traits, recombinant lines are useful because of their isogenic nature, because the genetic similarity of individuals allows for the replication of a quantitative trait locus analysis. 138. Stankus Inbred Strains of Mice and Rats survival, and growth patterns of B6C3F1 mice and F344 rats in the National C. J. and Watkinson W. P. (1995) Strain differences in the laboratory The replication increases the precision of the results from the mapping experiment, and is required for traits such as aging where minor changes in the environment can influence the longevity of an organism, leading to variation in results. L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive