Durable, low-linting, & available in white or blue. Binders, calendars, pens, cleaning and sanitation supplies, and office equipment are just some of the essential products we offer Science education supplies, specimens, activities, and equipment for all grade levels kindergarten to college. I{ w:ut\UvN;w!OM^g/z"/ B)t 4 0 obj true impacts are not quite known. WebChemical Compatibility of the Tubing Materials Name Tygon LFL Tygon ST R-3603 PharMed Tygon HC F-4040-A Tygon MH 2075 Tygon SI Silicone Platinum Silicone Although Labs does sell in plastic containers, it is not just any plastic. One difference is that DMSO-d6 is going to cost more. WebThe compatibility of DMSO with various materials is listed below: - Compatible: LDPE, HDPE, polypropylene, PPCO (polypropylene copolymer), polymethylpentene, nylon, WebWhy silicone rubber is inherently different from other elastomers 1.2 Major Classes of Silicone Rubber 9 How solid and liquid silicone rubber grades differ, and what characterizes them 1.3 Components of Silicone Rubber 10 Fillers, additives and catalysts, and their role in formulation 1.4 Curing 12 Avantor helps keep you safe with a robust line of safety products and personal protective equipment -- from waste bins to safety signs. PH?V8h~w;t)~g In the case that less polar cosolvents are included, it may be best to form a pregel in DMSO, followed by slow addition of the less polar cosolvent. The authors point out that dimethyl sulfoxide (DMSO) increases tissue perfusion and may effectively treat or prevent ischemia in flaps. DMSO is metabolized in humans by oxidation into dimethyl sulfone (MSM), or by reduction into dimethyl sulfide (DMS), both of which are excreted in urine and feces. endobj It is an effective solvent for a wide array of organic materials, including many polymers. Treatments were topically administered 3 times daily for 7 days, beginning immediately after surgery. Chemical Clear Search WARNING The Teflon - (PTFE) Polytetrafluoroethylene has outstanding resistance to chemical attack by most chemicals and solvents. Methocel E4M: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer, using spindle 61. Because of its small size and structure, DMSO molecules readily cross the membranes of skin, cells, and organelles.9 Furthermore, DMSO molecules can associate with a wide range of constituents, including water, proteins, carbohydrates, nucleic acid, and ionic substances. A premarket approval application is currently before the FDA for the Onyx LES Liquid Embolic System (Micro Therapeutics, Inc., Irvine, CA), a device that incorporates DMSO for embolization of arteriovenous malformations in the brain. 50 0 obj As expected, skin irritation (wheal and erythema with drying and scaling) was a common reaction to DMSO, but all reacting skin returned to normal within 3 weeks after treatment. 'PlZdN'L#LN6K5oM%o;sY@rg!k$-uHt6X@b3DbEIk $8C$V8H,pHo#!Hu;Ojq!Ts@ )+ (-qPZ@B2g like tween 80, tween 20 or DMSO if we want to dissolved it with Figure 1 demonstrates the immediate and obvious impact of DMSO on skin perfusion in a woman undergoing abdominoplasty. "y l3L]nW+*oaf T WebCellulose DMSO + 0.1 % LiBr PolarGel 50 5991-2517EN Cellulose acetate DMAc + 0.5 % LiCl PLgel 60 5991-5809EN Chitosan Water + 0.5 M NaNO 3 + 0.01 M NaH 2 PO 4 at pH endobj hmoF}O 0xlyAK=4WU(b[n#5< D-&I,Dib]M-VoM>OKX$,El9y2(B|Nn'IP0|_uuTxq ^DY$j4<==QxE^VOoOCdLe1fln}Xg:Vh0- _"x90# 'nq,LXh0Q|so@M=?IpiNi To avoid toxicity, limits to amounts of topical lidocaine need to be established, but the preparation used by Mallory et al included no more than 6 drops of 25% lidocaine, which is far less than the amount of drug delivered by injection. VWR/Anachemia continues to be the undisputed leader when it comes to supplying laboratories conducting mineral analyses around the world VWR is proud of our years of experience providing choice and excellent service to the Industrial market from Food & Beverage, Petrochemical, Environmental Testing, Waste Water, Cosmetics, Consumer Goods, Agriculture and more See how the unique Nalgene Rapid-Flow membrane support system provides the last line of defense against contamination. VWR is your complete source for workplace supplies. Avantor Services provides a wide range of specialized services and digital solutions to help you solve complex challenges. The products you use, the products you need, the suppliers you trust for chromatography. %PDF-1.2 Radioactive tracer studies of DMSO absorption in humans found that 5 minutes after cutaneous application, DMSO is detectable in the blood; after 1 hour, it is detectable in the bones.12, The free electron pairs of its oxygen atoms allow DMSO molecules to transfer electrons and accept hydrogen bonds. There were no significant differences in area of flap survival for the groups that received saline (71% survival), 8% H2O2 (72% survival), or 50% DMSO (76% survival). using spindle 64 for measurements at 1.5 % and 2.0% polymer. Consequently, the cause of ischemia should not be a consideration when contemplating DMSO treatment. 34Mackie EJB Dwyer NK Vanier MT Sokol J Merrick HF Comly MEet al. Avantor is now supporting customers active in research & development, production and recycling of advanced batteries. Gases Agilent Certified Vials, Caps and Septa - Postnova Assortment of popular, everyday Nalgene labware in a convenient pack. Solubility of Selected Polymers in DMSO / Tetralin mixtures The following codes are used to rate chemical resistance: VWR provides the cell culture community with access to the most reliable supply of exceptional quality Fetal Bovine Serum: VWR Life Science Seradigm. So much has changed during this unprecedented time, except your ability to count on Avantor. Freeze cells in tubes from 1 to 5mL using the Thermo Scientific Mr. Frosty Freezing Container at nearly -1C/minute. WebThis chemical resistance chart is intended for use as a guide, not as a guarantee of chemical compatibility. <>stream The Brobyn prison study demonstrated that even though topical DMSO does not seem to be toxic when given at doses 3 to 30 times the typical human dose for up to 3 months, it is not without side effects. The analgesic property of DMSO combined with its ability to rapidly deliver drugs into tissues may be applicable to topical lidocaine. What is DMSO and 11 Great Ways to Use It - Born to be Boomers 1 0 obj Did Billy Graham speak to Marilyn Monroe about Jesus? ;)(pP@)3RnP'iaz?P~mr[P Nothing herein constitutes permission, or recommendation to practice anyinvention covered by any patent without license from the owner of the patent. Before permanent installation, test the equipment with the chemicals and under the specific conditions of your application. 1. 2023 VWR International, LLC. :gJ+(:S(:PZYb3bg Inorganics w9i;`)z#^-z, 5. JavaScript seems to be disabled in your browser. Oils:Silicone Pyrogallic Acid DMSO was first synthesized in 1866 as a colorless organic solvent derived from byproducts of wood and paper pulp industries. WebAcetal (POM) Chemical Compatibility Chart Key to General Chemical Resistance All data is based on ambient or room temperature conditions, about 64F (18C) to 73F (23C) = Excellent B= Good - Minor Effect, slight corrosion or discoloration = Fair - Moderate Effect, not recommended = Severe Effect, not recommended for ANY use Compatibility Fog-free, soft sided, and splash resistant. Furthermore, the use of DMSO for treating closed head injuries is not an option in the United States, and no FDA-approved clinical trials are currently underway. gEJ(=S(=PZYb3bg No single pharmaceutical company was able to get an exclusive patent for DMSO; therefore, the pharmaceutical industry has not assumed the expense of studying DMSO beyond its uses as a drug component. Thermoplastic Ployurethane Elastomers (TPU) BASF Chairs & Stools. chloride). GBL Elastomer Compatibility Elastomer % Hardness Change % Weight Change % Area Change Color Change Percent Compatibility Pharmaceutically acceptable gelling agents suitable for the formulation of topical / transdermal DMSO products were evaluated to understand the effect of polymer loading on formulation viscosity. Since that discovery, more than 12,300 English-language articles about the medical implications of DMSO and its clinical mechanisms of action have been cataloged by the National Library of Medicine. Both topical and intravenous DMSO solutions have been studied in animal models of pedicle, island, and cutaneous flaps. endobj Chemical Resistance Guide Also in 1965, pharmaceutical companies noted a refractive index change in the lenses of dogs, rabbits, and pigs treated with DMSO at doses 50 to 100 times higher than typical doses used in humans. In another controlled rat study, 9 4-cm pedicle flaps were elevated on the abdomen. Pharmaceutical Excipient Solubility Data VWR's cell culture portfolio provides all the essential instruments, tailored to the needs of your cell biology processes. This would be especially helpful for treating children. RIk7+VQnWtQql-qz{`5^H8pLC_GsI'bc"Jng9+i3RIj%L.w}>+/UJ*G:JA6g']/M6;m\+vnSz[In}p,_2mM"]fhWfY9M7OV4kPa9fEqVi?UR;8QR(K%*C9Y)xqqwPEgQ(nTa$$U"3*+ WebThis is an initial guide for screening the suitability of silicone for contact with certain substances. Unfortunately, these kinds of claims can only confuse the actual and valuable applications of DMSO in medicine. endobj Q# $MVvoYR\rN:ndD%ym WebHere is the rubber compatibility chart that rates all popular rubber materials that comes into contact with various chemicals. For the best experience on our site, be sure to turn on Javascript in your browser. Dr. Stanley Jacob, considered the father of DMSO research, markets MSM and oral DMSO on his Web site (www.jacoblab.com) as a nutritional sulfur supplement ingested in liquid or crystal form. ) (-zP,zVXYb3bEJ(=S(=+P,zP,zC76aeMEo;tgE The animals were examined during the following 4 months for changes in their eyes, blood chemistry, hematology, urine, and neurological and cardiovascular systems.43 After 4 months, the monkeys were sacrificed and received gross and microscopic pathological examinations. Solvent mixtures can both Solvent Compatibility Chart - Restek Other Noveon rheology modifiers currently under evaluation include: Carbopol 940 NF, 934 NF, 980 NF, 934 NF, 981 NF, 1342 NF, 71G NF, 974 NF, Ultrez 10 NF, 971P NF. 2 = Swelling of plunger, possible peeling. DMSO got a reputation for toxicity in 1965 that has not been overcome, even though studies have determined that lens changes do not occur in humans or other primates treated with DMSO. Dimethyl Sulfoxide (DMSO), one of the strongest organic solvents, has been used commercially for several decades. 21Mallory SB Lehman PA Vanderpool DR Franz TJ, 22Sulzberger MB Cortese TAJr Fishman L Wiley HS Peyakovich PS, 24Santos NC Figueira-Coelho J Martins-Silva J Saldanha C. 31Perez RS Zuurmond WW Bezemer PD Kuik DJ van Loenen AC de Lange JJet al. 1. Herein we will discuss the potential uses of this substance in plastic surgery and then provide background information on chemical composition, FDA history, toxicity, relationship to tissue and flap perfusion, and other medical applications. DMSO is also approved as a component of pharmaceuticals, and its properties as a drug carrier are well known. The lenses were not opaque, and no microscopic or chemical differences were detected. Solubility of Selected Polymers in DMSO/Tetralin Mixtures, Solubility of Selected Polymers in DMSO/MIBK Mixtures. Other Dow rheology modifiers currently under evaluation include: Polyox WSR N10 NF, Methocel E5 LV, Ethocel Standard 4 NF and Ethocel Standard 10. WebChemical Compatibility Guide Polypropylene Dimethylsulfoxide (DMSO) Hydrogen Gas n-Amyl Alcohol Dioctyl Phthalate Hydrogen Peroxide (10%) n-utanol Formalin Magnesium Nitrate Oils:Silicone. Use suitable guards and/or personal protections when handling chemicals. + %PDF-1.5 WebLiquids tend to be miscible with liquids of a similar polarity, and the same is true for nonpolar substances. High-quality chemicals and services, customized to your product or manufacturing needs VWR enables the advancement of science by providing high-quality chemicals and services, customized to your product or manufacturing needs. 0=c=q1. Avantor can help maintain cleanroom standards with protective apparel and environmental monitoring equipment. Although DMSO probably cannot repair areas of necrosis, it may prevent loss of circulation in ischemic tissues or decrease the size of a possibly necrotic area. DMSO and plastic containers is an on going debate. Gels were measured at 73F (23C). The diameter of the measurement vessel was 8 cm. ?R}uNvdj=Z 5/j/>Tuc,A/8 SncEvDmQQr$Vw+t,GG*? =2Sp".Sr~yIk>Vn.Z2*IMWZMW!tMq These tables also show how solvency changes with the composition of the mixture, with ratio of the solvents selected, and show the composition of maximum solvency for each polymer and solvent pair. Polymer-to-Solvent Reference Table for GPC/SEC - Agilent We have become experts in scientific operations, improving performance with sophisticated solutions and providing guidance on best practices. Active Pharmaceutical Ingredients 2023 FORTUNE Media IP Limited All rights reserved. MK,\q5?#TY/!M"D+-5CV?:J:\WAe44>F_X"B.]u@}r[ihoD3,@C3i3rDyJPUm#%}{.. B)t 132 0 obj <>stream Clinical Outcomes in Patients With Bacteremia and Concomitant Left Ventricular Assist Devices and Cardiac Implantable Electronic Devices. + The purpose of the tests was to look for hepatic, renal, or hematologic changes. w9i;`y#^+z[Jw3Qzg They recommend application of topical DMSO every 4 to 6 hours, until blood flow improves, to areas that show signs of ischemia or less than adequate perfusion. The FDA status of DMSO is somewhat reminiscent of the history of silicone gelfilled breast implants. !cw Rubber Chemical Resistance Chart - Mykin The diameter of the measurement vessel was 8 cm. The 2 photos were not taken from the exact same angle, but the effects of DMSO are evident. WebSilicone (PDMS) Chemical Compatibility Silicone (PDMS) Chemical Compatibility WARNING. Pakistan ka ow konsa shehar ha jisy likhte howy pen ki nuk ni uthati. Cleanrooms or other controlled environments used for research or manufacturing need specialized products. The application of DMSO cannot salvage every compromised flap, but we have witnessed its benefits when used on flaps that show signs of ischemia. The mean PtcO2 value also was significantly different for the DMSO + H2O2 group (95% versus 74% for the other 3 groups). B, Same patient 12 minutes later. Clinical Characteristics of Pediatric Patients With Septic Shock Caused by Acute Appendicitis: A Case Series. Streamline your workflow storage with VWR Ultra- Low Temperature Upright Freezer. WebThis chemical compatibility listing is based on using our standard compounds DuPontKalrez7075 and 6375 for the vast majority of chemicals and fluids. In 1968, McFarlane et al2 reported on the use of DMSO to prevent necrosis in experimental pedicle flaps; numerous studies that followed confirmed this discovery.36 The mechanism of action is not fully understood, but DMSO is known to stimulate histamine release,7,8 and histamine release triggers vasodilation. It is recommended to test under your own conditions. Chemical Compatibility V. Leroy Young, MD, 969 N. Mason Rd, Suite 170, St. Louis, MO 63141. It is believed that DMSO protects the integrity of cell membranes during injury,48 especially defending against attack by hydroxyl radicals, which are generated at a high level after ischemic injury. Using various dyes as visual tracers, followed by biopsies, a study of DMSO penetration into human skin demonstrated that the stratum corneum was completely stained.22 Thus, DMSO penetrated rapidly and deeply into the horny layer. Chemical Compatibility Guide Data analysis revealed no significant differences among those receiving DMSO or the controls on any variable, with one exception: a small percentage of treated subjects had a slightly elevated peripheral eosinophil count. No ocular or lens abnormalities occurred in the treated subjects. He also uses topical DMSO to maximize the area of skin resection in patients undergoing abdominoplasty, thereby maintaining good flap perfusion. Several different mechanisms may explain how DMSO counteracts ischemia after trauma. + startxref -iKI;Xm8x;];qdzqQ%`1!]k^?fN"]Xb.D~OA^3?6Un5%R;3j:c`72zFJ2)g@#hAR)zFD^0QodC.?JR:W5R? DMSO can carry nonionized molecules through skin if their molecular weight is less than 3000. ) (-zPZ@BYb3b0L=@+XTs@) (-zPZ@Bg Gels were measured at 73F (23C). WebChemical Compatibility of Ultrafiltration Products and Centrifugal Filters. Gaylord Chemical can provide product samples to qualified users of chemical products. Inhibits growth of or inactivates bacteria. Injections of DMSO into the spinal cord soon after injury have shown great promise for restoring function. Antioxidants, such as vitamin C, are important components of good skin care. e( l8fs\KPnN3 S|7T8()gqlC2v1T!N3D_e4%8>=sR8B\|5H8SW"2KOSDG-*pHaGH'O0g; NM For information visit, www.avantorsciences.com and find us on LinkedIn, Twitter and Facebook. V. Leroy Young, MD, St. Louis, MOis a board-certified plastic surgeon and an ASAPS member. Vinnik5 has reported that he achieves maximal tissue expansion in minutes by applying topical DMSO, which permits immediate placement of large permanent implants after mastectomy. The contents of this page summarize solubility characteristics for DMSO. %%EOF As our customers needs have evolved, so have our capabilities. As your trusted, collaborative partner, Avantor Services helps you increase efficiency, maximize productivity, and accelerate innovation. !eF]q7F w9i;`y#^-z ^5~f~MEo;tgE In effect, the attractive or repulsive forces between molecules in the mixture will be approximately equal although additional types of molecules have been added. WebSilicone (VMQ) Viton (FKM) Acetaldehyde D A A D D B C C D A D Acetamide (Ethanamide) A BD Acetate Solvents (Ester Solvents) C A A D D D C D D C D and maintenance of these products. $WtjqYt=77y]nOqo2UN?QsMT6!;IkH!UD\;d07\2I"|W+%S4? water. One of the more intriguing characteristics of DMSO is its potential to increase perfusion in injured tissues. Use the dropdowns below to search by material, chemical or both. The epigastric vein was occluded with a clamp for 8 hours before the clamp was removed and the flap resutured to its bed.9 Two groups of animals received intraperitoneal saline. The area of flap survival was measured with a sonic digitizer. In addition, there was a significant difference in the average inflated volume per session; the untreated group had an average of 90 mL added to their expanders per session, compared with the DMSO-treated group who had an average of 120 mL added to their expanders per session. Much lower concentrations of DMSOin the range of 1% to 8%are sufficient for crossing membranes other than skin. The literature review indicates that the ability of DMSO to cross all membranes varies according to DMSO strength. Instrument settings of 100, 30, 12 and 5 RPM were used for samples containing 0.5, 1.0, 1.5, and 2.0 wt% polymer, respectively. Use this rubber chemical resistance chart to make sure that the elastomer or O-ring seal you choose will be compatible with the particular environment. It is believed that the anti-inflammatory and muscle relaxant properties of DMSO are responsible for the improvement in patients with interstitital cystitis. 1. 3 0 obj Mixtures with two or more different chemical types/classes should be reviewed with the Kalreztechnical group or your authorized Kalrezdistributor before proceeding. <>]/Pages 46 0 R/Type/Catalog>> Good experimental and anecdotal evidence indicates that DMSO increases tissue perfusion and may effectively treat or prevent ischemia in flaps. :gJ+(:S(:PZYb3bg Masterflex does not warrant (neither express nor implied) that the information in this chart is accurate or complete or that any material is suitable for any purpose. The molecular weight of lidocaine is 234. Mix Dimethyl Sulfoxide and wWQ=}yVlo\_-mfr_^-Wl9Z|uS7Ww?7t40L]{x.]il7{Kx~y9Gn? However, there has been a lack of development in the potential medical applications of DMSO. Do Eric benet and Lisa bonet have a child together? We have personally had success using topical DMSO to improve skin perfusion following abdominoplasty and face lift procedures, and would definitely consider using DMSO in conjunction with other procedures that pose a risk for ischemia. 1 = Possible crystallization, blockage, or possible coat peeling. Tubes made of which material are compatible with DMSO? Used under license. Relative Hansen Solubility Parameter Data l.9#2wx;%z, s54 `x|yh5\UC7fGEDh.HuLt! The information in this bulletin is based on information available to us and on our observations and experiences. How to Use the Chemical Compatibility Chart Vials and The FDA status of DMSO is somewhat reminiscent of the history of silicone gelfilled breast implants. 50% DMSO solution. For example, patients would not have to wait as long before receiving painful injections, including tissue fillers, and suturing could be completed more quickly, and without lidocaine injection. Sign up for our newsletter and receive periodic engineering tips on good seal desing practices. One group of 20 patients underwent standard tissue expansion, and in another group of 20 patients, 60% DMSO-soaked surgical sponges were left on the skin overlying the expander for 30 minutes prior to expansion. Resection should always be kept within safe margins. Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1. :"R5dIv5%&^FK.SDhWC5s] [tO?cp^!THws22@vigAu!`Uk7Ez Tables 9 and 10illustrate how the solvency of a mixture for selected polymers can be related to the composition of the mixture. These gloves offer the perfect combination of improved elongation with outstanding protection from chemotherapy drugs, and an FDA-approved low dermatitis potential claim. <>/PageLabels 2395 0 R>> DMSO with H2O2 was studied because H2O2 stimulates the release of oxygen when applied to tissues, and DMSO penetrates cell membranes; so, theoretically, DMSO could deliver hydrogen peroxide throughout the flap. 20Somei K Mizuma K Nara K Matsuya H Yoda J Sasaki Ket al. In this model, 10 2.5-cm flaps were elevated and then resutured on the backs of rabbits.6 Four groups were compared: (1) those treated with saline; (2) those treated with 8% hydrogen peroxide (H2O2); (3) those treated with 50% DMSO; and (4) those treated with 50% DMSO + 8% H2O2. Dimethyl sulfoxide [(CH3)2SO] (DMSO) is an organic solvent of which plastic surgeons should be aware, primarily because its ability to increase perfusion has led to its use in decreasing ischemia in tissue flaps. 2 0 obj <>stream We continue to set science in motion to create a better world by providing you with the right solutions to keep moving forward. 4. Avantor supports end-to-end fluid management solutions including peristaltic pumps and aseptic fluid transfer solutions that are reliable and customer-centric, helping bioprocessing manufacturers meet their research and production goals. WebHere is the rubber compatibility chart that rates all popular rubber materials that comes into contact with various chemicals. Compatibility WebAcrylic aka PMMA Chemical Compatiblity Chart - D. Acrylic (PMMA) thermoplastic is notable for its clarity, long service life and UV resistance. '-nb*${b4Y,Ox2d'#)_qa,?/} ynDUxM3oSe>%IIUgC{be`LezL#sOZi2@ 80 0 obj It does not appear to dissolve silicone, especially in breast implants, but its true impacts are not quite known. The US Food and Drug Administration (FDA) halted all human studies of DMSO in 1965 when a woman in Ireland died of an allergic reaction after taking DMSO and several other drugs; however, her cause of death was never precisely determined. used. <>/Filter/FlateDecode/ID[<0DF17C147D44C6499011D01672A63D81>]/Index[50 31]/Info 49 0 R/Length 91/Prev 589283/Root 51 0 R/Size 81/Type/XRef/W[1 2 1]>>stream endobj You can select and customize services for peak efficiency, quality, and accelerated innovation. Chemical Compatibility of Filter Components - EMD + We use operational excellence to deliver solutions that enable research, testing, production, and commercialization across the globe. Avantor can help you plan, design, and configure a custom laboratory environment that meets all your needs. x][o7~7/,vE``YlE]ptH{&Y4}"YEVuCo? endstream It does not endobj 1 0 obj <> endobj 2 0 obj [ 3 0 R] endobj 3 0 obj <>/Border[0 0 1]/C[0 0 1]/Rect[ 345.5 26.6 540 38.7999]/Subtype/Link/Type/Annot>> endobj 4 0 obj <>stream k0jX^&qIs&E?8Z4hTrYI 5 5( A0en=EOAs3 WARNING - PermSelect It is best dissolved in DMSO but 100% ethanol also can be DMSO is miscible with water and most organic liquids. Newer forms of DMSO, such as MSM, which is also known as DMSO2, are available that do not produce this odor, but they lack scientific testing. <> endstream }iEd$U/b6@CRWm'b//edI?-W/:TI?~2?k:* 7#n"`gJ}+OFBvtBCE 2JU$aP%pM@*P\{ ~A~D)eeeckDgCP\3U(1LP8)^J8 H$ve$4$W,\XPbUlX~[*ZEbT9w_TVee\yh*u 05 *#$k#hRye+{ WebHighly polar organic solvents such as dimethylformamide (DMF), dimethylsulphoxide (DMSO), N-methylpyrrolidine and tetrahydrofuran (THF) dissolve thermoplastic polyurethane. This eosinophilia was believed to result from the cutaneous histamine-releasing effect of DMSO. Methocel A4M: All viscosity measurements were recorded using a Brookfield Model DV-E Digital Viscometer using spindle 61 for measurements at 0.5, 1.0 and 1.5 % polymer. Ratings - Chemical Effect A - Excellent- B - Good: Minor Effect, slight corrosion, or discoloration. 2McFarlane RM Laird JJ Lamon R Finlayson AJ Johnson R, 3Grossman JA McGonagle BA Dowden RV Dinner MI, 10Rand-Luby L Pommier RF Williams ST Woltering EA Small KA Fletcher WS, 12Kolb KH Janicke G Kramer M Schulze PE Raspe G, 19Tsai JC Guy RH Thornfeldt CR Gao WN Feingold KR Elias PM. One study of abdominal island flaps in rats compared control animals that received saline injections with rats injected with intraperitoneal DMSO. DuPont Kalrez Chemical Resistance and Fluid An unfortunate side effect of DMSO used in any form (intravenous, injected, or topical) is that it causes a garlic-like breath odor that is not only unpleasant but also poses an alert that makes it difficult to conduct DMSO blinded clinical trials.13 Also, skin care products that caused a garlic-like breath odor would be a challenge to market.