When this is not possible, long-term management usually requires continuation of the hydrolyzed, amino acid-based, or nutritionally complete novel protein diet. Contact your closest emergency pet hospital. A263921. Methane-dominant SIBO tends to cause constipation, and hydrogen dominance causes diarrhea. Mix up enough formula for 3-4 hours at a time. Ive done it before, and so have many clients of Dr. Mike T. Nelsons. Per FDA guidelines for therapeutic pet food, you need a prescription forPurina Pro Plan Veterinary Diets. Use a blender to make the shakes nicely frothy. Ghoshal UC, Srivastava D. Irritable bowel syndrome and small intestinal bacterial overgrowth: meaningful association or unnecessary hype. Systematic review: nutritional therapy in paediatric Crohns disease. It contains low-allergen carbohydrates to reduce the risk of an allergic reaction along with easily digestible ingredients to promote optimal nutrient absorption. Steering the Elimination Diet Trial Towards Success | VETgirl Dr. Michael Ruscio, DC on July 30, 2020 No. Item #: 578.00162.5 . They may help manage even the most highly sensitized animals. It's sold as a powder that you simply mix, blend or shake up with water. Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Nestl Purina PetCare has released a therapeutic dog food formulated to assist in elimination diet trials and the nutritional management of dermatological and gastrointestinal conditions. We will ONLY use your email to notify you in regards to your submission. Purina offers an array of dog food products, specially formulated to meet your dog's unique needs. Purina Pro Plan Adult Shredded Blend Chicken & Rice Formula. Sign up to automatically ship your next purchase so you never run out of food. Learn more about how Calming Care helps dogs maintain calm behavior on package labels or on this websites Calming Care page. Purina Pro Plan Veterinary Canine Diet EL Elemental 8 lb. I certify that I have read and accept the, Purina Pro Plan Veterinary Diets EL Elemental Canine Formula, Do Not Sell or Share My Personal Information, 4-3/8 cups plus 1/4 cup for each 10 lbs (4.5 kgs) of body weight over 100 lbs, Formulated with purified amino acids to support dermatological and gastrointestinal health in dogs with adverse food reactions, Low-allergen carbohydrate sources to help minimize the risk of an allergic reaction, Highly digestible to promote optimal nutrient absorption, Limited fat to aid digestion for dogs with compromised gastrointestinal tracts, Contains vegetable oil (a source of medium-chain triglycerides), Contains omega-3 fatty acids, a source of EPA and DHA, omega-6 fatty acids, vitamin A and zinc to maintain the skin barrier, Contains prebiotic fiber to help nourish the GI tract. Probiotics, prokinetics (for some patients) and a low FODMAP diet can all be very supportive. The elemental diet is a meal replacement formula that is hypoallergenic, anti-bacterial and anti-inflammatory. Enteral nutrition in Crohns disease: an underused therapy. A list of the additional impacted product is below. Many people use a low FODMAP diet to control symptoms, but sometimes that doesnt help. Levine A, Turner D, Pfeffer Gik T, et al. Individual ingredient challenges should be used to identify those ingredient(s) to which the pet is allergic or intolerant. I certify that I have read and accept the Notice at Collection . Typically, the prescription food is given to pets with food sensitivities. Even a half elemental diet (up to 50% of daily calories from elemental shakes) reduces gut symptoms and flares [18]. Purina for Professionals | Homepage Since no whole foods are being consumed, your gut also gets a break from food intolerances and irritants. Purina has high-quality food and treats that your pet will love! The Elemental Diet: An Effective Therapy for Gut Relief Purina Pro Plan Veterinary Diets EL Elemental Canine Formula Get the latest Rx offers and new Rx Products, 2023 Copyright Agropec Trading LLC. Keep out of reach of children and animals. Parents might feel guilty and sad about taking food away from children., The special formulas on an elemental diet may also taste unpleasant. Therapeutic Dog Food & Supplements | Pro Plan Vet Direct Elemental diets also help to rebalance bacterial overgrowths, decreasing bad bugs and making space for a healthier microbiota [23]. Its meant for people with serious health conditions and should be monitored by a health-care provider. For more information, consumers can visit Purinas website or call 1-800-345-5678 Monday through Saturday, 8 a.m.- 5 p.m. CST with any questions or a refund request. It contains a Shop Chewy for the best deals on Purina Dog Food and more with fast free shipping, low prices, and award-winning customer service. Nestl Purina Petcare Company Expands Voluntary Recall of Purina Pro Purina Recalls Pro Plan Veterinary Diets EL Dry Dog Food Due to $30.99 Purina Pro Plan Veterinary Diets FortiFlora Dog Supplement for Dogs with Diarrhea, Box of 30 Product Details Product Description Purina Pro Plan Veterinary Diets EL Elemental Formula Dog Food is a prescription food specially formulated support the dermatological and gastrointestinal health in dogs with adverse food reactions. Your immune system attacks your intestines and causes damage. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohns disease: a randomized controlled open-label trial. Purina Pro Plan Veterinary Diets EL Elemental comes in 8- and 20-pound bags. Purchase your pets food online through Vet Direct, with the convenience of home delivery and automatic shipments. When shes not writing or editing, Jessica is bound to be planning out her next travel adventure, trying out a new coffee spot or listening to a podcast. (2) The Ruscio Institute is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. Mueller, R. S., & Unterer, S. (2018). However what I see in the clinic is that many of these symptoms will often improve, sometimes dramatically, when you improve your gut health. Fortunately, no other Purina products have been impacted by this recall. Clinically, I have found elemental diets to be very effective for all of these conditions and even some others not mentioned in the research, such as reflux. Cold shakes taste best. The following feeding program is recommended as a guideline only, with discretionary clinical adjustments for proper weight maintenance.FEEDING GUIDE. Nestl Purina Petcare Company Voluntarily Recalls Purina Pro Plan Veterinary Diets EL Elemental Dry Dog Food in the U.S. Due to Potentially Elevated Vitamin D. New Customer? No food other than the elimination diet should be fed during the trial. Drink as much Elemental Heal as you like. As the name implies, SIBO is a digestive problem in which too much bacteria grows in the small intestine. Ruemmele FM, Veres G, Kolho KL, et al. You also can sign up to receive the Todays Veterinary Business weekly e-newsletter. For your pets health, see your veterinarian regularly. 2019: The Science of Cats: Challenging Perceptions. Pet Food / Dog Food / Purina Pro Plan Veterinary Diets EL Elemental Formula Dog Food, Save 5% Many pet owners will have tried numerous diets prior to seeking veterinary care for their pets potential adverse food reaction. EL Elemental can be used to diagnose and nutritionally manage dogs with adverse food reactions. I switched to the Pro Plan and it cleared right up. Some underweight patients may actually gain weight on an elemental diet because they start to absorb nutrients better. Changing the Conversation. MacLellan A, Moore-Connors J, Grant S, Cahill L, Langille MGI, Van Limbergen J. Food allergy in dogs and cats: A review. Nestl Purina Petcare Company Expands Voluntary Recall of Purina Pro Plan Veterinary Diets El Elemental Dry Dog Food in the U.S. Due to Potentially Elevated Vitamin D. This article is based on scientific evidence, written by experts and fact checked by experts. I care about answering your questions and sharing my knowledge with you. With less inflammation, malabsorption improves and the small intestine can absorb more nutrients. Sorry, you need to enable JavaScript to visit this website. There fur is shiny and skin healthy. The same goes for veterinary and retail partners of Purina, who the FDA advises to remove and destroy the food from their inventory. A pilot study comparing an elemental diet with oral prednisolone. In response to an elimination diet, improvement in gastrointestinal signs may be seen within 1 to 4 weeks or in dermatological signs within 4 to 8 weeks. As pet experts and pet parents ourselves, the health and well-being of pets is our top priority, and all necessary measures are being taken to ensure this error is never repeated. When to Switch From Kitten Food To Cat Food? Otherwise, elemental diets as a treatment for autoimmunity have not been well-researched. This can lead to malnutrition, dehydration, and other serious problems.. Written by Dr. Michael Ruscio, DC on Well, theres little research looking at these. The full elemental option (whey-free) is best for those who are sensitive to whey. Dr. Michael Ruscio, DC. Purina Pro Plan Veterinary Diets HA hydrolyzed chicken flavor dry dog food (based on hydrolyzed chicken) Purina Pro Plan Veterinary Diets EL Elemental Canine Formula Dry Dog Food (which isn't technically hydrolyzed, but it's made with individual amino acids rather than protein pieces) In particular, products with the UPC code 38100 19190 on 8-pound bags and 38100 19192 on 20-pound bags are affected. That's why we're proud to offer a full spectrum of performance and specialized nutrition formulas, including options that support healthy aging, reduce cat allergens, provide guaranteed live probiotics, and more. Elemental diets were developed as a medical food to treat patients with severe digestive issues. Dry Dog Food, Purina Pro Plan Elemental diets usually last 2 to 6 weeks to allow healing or other treatment, depending on the condition. (2006). Jackson, H. A., Jackson, M. W., Coblentz, L., & Hammerberg, B. Semi-elemental diet shakes taste better, so this is the best choice to help you stick with the diet. I developed the best-tasting elemental formula yet, Elemental Heal. Again. All trademarks are owned by Socit des Produits Nestl S.A. or used with permission, I would like to receive periodic emails, special offers and other marketing communications from Purina Pro Plan Veterinary Diets and Purina and its brands. Purina Pro Plan Veterinary Diets Digestive Health Bites Dog Treats, 16 oz., Case of 5, 5 X 16 OZ. These flares can cause symptoms like: If flares last a long time, you have a high risk for dehydration and malnutrition, especially if there is diarrhea.. For over 80 years, we've been guided by the belief that pets and people are better together. Always AdvancingAllergy-Focused Nutrition Comprehensive Care ForAll Allergy Patients. Get Started. Theres a lot of conflicting information about coffee. This can make finding a novel protein source challenging. When it comes to dog food, lots of pup owners have adog food brand preference. You do not need a prescription for Purina Pro Plan Veterinary supplements. Otley AR, Russell RK, Day AS. There are a number of prescription and non-prescription elemental formulas. Purina Pro Plan Veterinary Diets Pick a newer, better tasting formula as it will make sticking with the diet much easier. Rajendran N, Kumar D. Role of diet in the management of inflammatory bowel disease. $13380 ($133.80/Ounce) FREE delivery Thu, Apr 27. (new Image()).src = 'https://capi.connatix.com/tr/si?token=38cf8a01-c7b4-4a61-a61b-8c0be6528f20&cid=877050e7-52c9-4c33-a20b-d8301a08f96d'; cnxps.cmd.push(function () { cnxps({ playerId: "38cf8a01-c7b4-4a61-a61b-8c0be6528f20" }).render("6ea159e3e44940909b49c98e320201e2"); }); While healthy amounts of vitamin D are beneficial and imperative to canine health, an excess can cause several health issues. Shop Now. Unavailable at this time. However, when it comes to one of the most popular dog food brands, owners may need to check their pantry. Every product is science-based, validated by real-world use, and personally vetted by Dr. Ruscio, DC. 2018: Gerontology: An inside out perspective, 2017: The nexus of pet and human nutrition, Prevent clicks on page when mobile menu is being shown, Do Not Sell or Share My Personal Information. Heres everything you need to know to keep your dog happy and healthy. Comparison of outcomes parameters for induction of remission in new onset pediatric Crohns disease: evaluation of the porto IBD group growth relapse and outcomes with therapy (GROWTH CD) study. Symptoms include: This condition can make it hard to eat, which can lead to weight loss and other problems. Are you sure you want to add it again? Diet elimination trials are the gold standard for the diagnosis of food allergies and food intolerances,1,2 considered adverse food reactions. Ask your veterinarian if PurinaPro PlanVeterinary Diets products can help manage your pets health. 4 Many pet owners will have tried numerous diets prior to seeking veterinary care for their pet's potential adverse food reaction. Buy Purina Products | Save On Purina for Cats and Dogs - WalmartPetRx It's our most advanced elimination diet yet. Plan to support your gut health once the diet is over. An elemental diet is very restrictive and can be hard to stick to. It comes in multiple flavors including vanilla, chocolate, and peach. Ingredients : Corn starch, tapioca starch, dicalcium phosphate, partially hydrogenated canola oil preserved with TBHQ, glycine, L-Glutamic acid, coconut oil, L-Alanine, L-Aspartic acid, powdered cellulose, L-Lysine monohydrochloride, L-Arginine, L-Leucine, sodium bicarbonate, L-Proline, L-Serine, potassium chloride, corn oil, L-Valine, tricalcium phosphate, L-Threonine, DL-Methionine, L-Isoleucine, salt, L-Phenylalanine, soy lecithin, fish oil, L-Tyrosine, L-Histidine, inulin, L-Tryptophan, choline chloride, taurine, magnesium oxide, Vitamin E supplement, zinc sulfate, ferrous sulfate, manganese sulfate, niacin (Vitamin B-3), soybean oil, Vitamin A supplement, copper sulfate, calcium pantothenate (Vitamin B-5), thiamine mononitrate (Vitamin B-1), Vitamin B-12 supplement, riboflavin supplement (Vitamin B-2), pyridoxine hydrochloride (Vitamin B-6), garlic oil, calcium iodate, folic acid (Vitamin B-9), menadione sodium bisulfite complex (Vitamin K), Vitamin D-3 supplement, biotin (Vitamin B-7), sodium selenite. Purina Pro Plan Veterinary Diets EL Elemental is an amino acid-based diet, formulated for dogs with food sensitivities. By subscribing to automatic shipments, you agree to the Terms of Sale including the subscription program terms and conditions. Elemental formulas are easy to absorb and not irritating for your digestive system because: As you consume elemental meals, your digestive system gets a break from performing its many functions, allowing it to rest and regenerate [19]. If you think your pet could benefit from therapeutic . Orders after 2 PM EST may be delivered the following business day. The formulas used in an elemental diet usually come in liquid or powder form.. Nestl Purina Petcare Company Voluntarily Recalls Purina Pro Plan (2019). Elemental diets have been critical in managing human patients with allergic disease and severely compromised GI tracts, said Jason Gagn, DVM, DACVN, director of veterinary technical communication for Purina Pro Plan Veterinary Diets. Food is a prescription food specially formulated support the dermatological and But remember, your gut has a strong influence on your immune system, and thus, anything you do to improve your gut health may help with autoimmunity [53]. They may help manage even the most highly sensitized animals. PURINA PRO PLAN VETERINARY DIETS EL Elemental Canine Formula Dry Dog If youre feeling sluggish and foggy because of poor food choices, a gut reset can help to get you back on track. And while the observational data from clinicians is promising, we need to be careful not to overstate the evidence. Studies have shown that over-the-counter novel protein diets may contain ingredients not listed on the label including, potentially, the protein or ingredient intended to be avoided. Were donating $1 for every order placed on Vet Direct between January 15-June 30 to the AVMFREACH (Reaching Every Animal with Charitable Healthcare) Program, up to $200,000. Learn more on package labels or on this websites NeuroCare page. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers. Explore them all here. Food allergies and food intolerances are types of adverse food reactions. The original announcement was made on February 8, 2023. When submitting a question, you agree to the Terms and Conditions.Questions & answers are usually published within a day once approved. Each diet is formulated specifically to meet unique nutritional needs, often with innovative ingredients backed by the latest research in pet nutrition. We fully recognize that dog owners who rely on PPVD EL Elemental are anxiously awaiting its return to market, and we are working hard to make this unique and life-changing formula available again within the next few months. Yes. My dog's vet prescribed this when Purina Elemental was recalled. Bags of PPVD EL with the UPC Code and Production Code below should be immediately discarded. PURINA DOG FOOD (Free Shipping) | Chewy OM Metabolic Response + Joint Mobility uses a unique 3:1 protein-to-starch ratio as well as a high level of omega-3 fatty acids (EPA). Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohns disease. Did you know a subscription to Todays Veterinary Business is free to qualified veterinary professionals? The original and newly issued recalls are due to the findings of potentially elevated vitamin D levels within the affected dry dog food. Amino acid-based enteral diets may help reduce potential complicating factors inelimination diet trials, including sensitization to multiple allergens, failure to select novel proteins and persistent allergenicity of hydrolysates, Purina reported. EL Elemental is made with high-quality ingredients. Since its a very safe treatment [43, 44, 45], patients can simply do a trial of the elemental diet and see if it works for them. These issues depend on the level of vitamin D and the length of exposure dogs experience to it. This has been noted especially in patients with Crohns disease [20, 21, 22]. Orders placed before 2 PM EST Monday - Friday will be delivered same day. Manufacturer Item: 0038100191905. SIBO can be hard to treat because bacteria can become resistant to antibiotics and quickly grow back. An elemental diet may also ease symptoms of digestive disorders like: Some people are drawn to the elemental diet for weight loss. Purina Pro Plan Veterinary Canine Diet EL Elemental 8 lb . Knight C, El-Matary W, Spray C, Sandhu BK. Sorry, you need to enable JavaScript to visit this website. So, if we go back to the SIBO study, we see that for 65% of patients who followed an elemental diet for 14 days, IBS symptoms improved [42]. The Future of Functional Medicine Review: Elemental Heal (Gut Healing Meal Replacements), Cold Exposure is Backed by ScienceHow it Benefits Health, Research-Backed Natural Remedies for Mood, Heart Health, & More, How to Know Youre Overtraining (And What To Do About It). If you are managing an inflammatory condition, its not unusual to have an occasional flare up. Get Started. Hydrolyzed diets contain proteins broken into small pieces that are less likely to elicit an allergic response even if the pet is sensitized to that protein. EL Elemental is made with high-quality ingredients. When to Switch From Kitten Food To Cat Food? It's a great choice for patients who don't respond well to other elimination diets and are still suspected of having a food sensitivity. New Kitten Checklist: What Does a Kitten Need? All Rights Reserved. Verlinden, A., Hesta, A., Millet, S., & Janssens, G. P. J. From energy and immune health to strong muscles, including a healthy heart, these high-quality formulas combine nature and research for results you . (2003). Using an elemental diet as your only source of calories for 2-3 weeks often achieves results when other gut therapies have failed. *Nestl Purina PetCare Company will donate $1.00 to the American Veterinary Medical Foundation (AVMF) in support of its REACH (Reaching Every Animal with Charitable Healthcare) Program for each order placed on www.proplanvetdirect.com (the Website) between 1/15/23 and 6/30/23, subject to a maximum total donation of $200,000. The affected dry dog food was distributed throughout the United States by prescription only through veterinary clinics, Purina Vet Direct, Purina for Professionals, and other select retailers with the ability to validate a prescription. As assistant editor of all things trends, Jessica writes about everything and anything from the latest travel updates to restaurant news to insects for Readers Digest, Taste of Home and Family Handyman. Prevent clicks on page when mobile menu is being shown, Purina Pro Plan Veterinary Diets Canine and Feline Formulas, Home Delivery with PurinaPro PlanVet Direct. Purina Pro Plan Veterinary Canine Diet EL Elemental 8 lb Following a strict elemental diet for 2-3 weeks may not be necessary if youre not struggling with a severe gut condition. (optional). acids, a source of EPA and DHA, omega-6 fatty acids, vitamin A, zinc, and Purina Pro Plan Veterinary Diets EL Elemental (PPVD EL) 8 lb and 20 lb bags. Nestl Purina Petcare Company Voluntarily Recalls Purina Pro Plan Veterinary Diets El Elemental Dry Dog Food in the U.S. Due to Potentially Elevated Vitamin D When a company announces a. Explore our easy-to-use and research-backed supplements today. Cross one errand off your list! Consume elemental shakes exclusively for 24-48 hours and then restart your healthy diet. Some of the original Elemental formulas, such as Vivonex Plus, have a reputation for tasting like glue. Learn More. The affected Purina products were distributed nationwide by prescription to veterinary clinics, Purina Vet Direct, Purina for Professionals and select retailers who can validate a prescription. These are the only whey free (fully elemental) and low carb elemental diet formulas available without a prescription. Many SIBO patients have IBS symptoms, including diarrhea, constipation, bloating, cramping and abdominal pain. Purina Pro Plan Veterinary Diets offer multiple nutritional options specifically tailored to a variety of dogs and cats with special needs. Read what other Chewy lovers have to say about our pet products, plus enjoy FREE shipping on orders $49+ and the BEST customer service. Kansal S, Wagner J, Kirkwood CD, Catto-Smith AG. Coyner, K., & Schick, A. Total Dietary Fiber 0.83 g / 2.75% / 3.02%, Copper 0.45 mg / 15.09 mg/kg / 16.55 mg/kg, Vitamin A 329 IU / 10,940 IU/kg / 12,004 IU/kg, Vitamin E 16.25 IU / 540 IU/kg / 592 IU/kg, Total Omega-6 Fatty Acids 0.47 g / 1.56% / 1.71%, Total Omega-3 Fatty Acids 0.14 g / 0.46% / 0.51%, web/xmlpackages/product.SimpleProduct.xml.config. Purina Pro Plan Veterinary Diets | Purina Canada According to Purina, the expanded recall comes on the heels of an investigation prompted by the company. That's why we're proud to offer a full spectrum of performance and specialized nutrition formulas, including options that support healthy aging, reduce cat allergens, provide guaranteed live probiotics, and more. In these cases, an elemental diet can be helpful. In some countries, such as Japan, elemental diets have become the first line of treatment because corticosteroid drugs have some troublesome side effects [50]. An elemental diet is a very restrictive diet that replaces foods and drinks with special formulas. Probiotics can also be a helpful follow-up to a gut reset. The bulk of research into elemental diets is focused on IBD. Company Announcement. The difference is in how completely the proteins in the formula have been broken down: either fully into amino acids or partly into whey protein. Hydrolyzed protein diets for dogs and cats. The science behind our therapeutic diets represents a collaboration among Purina nutritionists, researchers and veterinarians. No product order inquiries. This diet has a reputation for being challenging to follow, however the newer, better tasting formulas make it a lot easier. I also recommend adding a healthy oil, like MCT oil, to the shakes. Vitamin D toxicity may include vomiting, loss of appetite, increased thirst, increased urination, and excessive drooling to renal (kidney) dysfunction. Purina Dog Food recall 2023: Expanded list and all you - Sportskeeda There are two versions of the elemental diet, the full elemental diet and the semi- or half-elemental diet. Purina: Nutritious Dog and Cat Food for Your Pet Introducing CC CardioCare, made with a Cardiac Protection Blend composed of amino acids and fatty acids (omega-3 and medium-chain triglycerides), magnesium and vitamin E. Learn More Revolutionizing The Elimination Diet EL Elemental is built with purified amino acids. These products, including Calming Care, FortiFlora and Hydra Care, can be purchased from Pro Plan Vet Direct, Amazon or Chewy.com, select pet specialty retailers or your veterinarian. Purina Pro Plan is the most advanced nutrition for your pet's best life. NeuroCare does not have any expected negative side effects. Purina Pro Plan Veterinary Diets EL Elemental Formula Dog Food Try Pro Plan today and discover what advanced . These special foods often have to be prescribed by your doctor. New Kitten Checklist: What Does a Kitten Need? Takagi S, Utsunomiya K, Kuriyama S, et al. Most of the bacteria in your gut is in the large intestine rather than the small. We are no longer supporting IE (Internet Explorer), You Shouldnt Go Another Day Without These Editor-Loved, No-Tear Tights In Your Closet, Canine Parvovirus Is on the RiseHeres What You Need to Know, The Real Reason You Shouldnt Play Fetch With Sticks With Your Dog, Do Not Sell or Share My Personal Information. Nestl Purina has expanded their original Feb. 8 voluntary recall of a select prescription dry dog food due to a supplier error, which can result in some serious pup illnesses. Purina offers an array of dog food products, specially formulated to meet your dogs unique needs. The bacteria ferment the food fibers and release gas. Please contact our team directly Monday - Saturday, 8am - 5pm CST at 1-800-345-5678 or via email at https://www.purina.com/contact- us for questions or assistance in getting a refund. Adverse food reactions: Pathogenesis, clinical signs, diagnosis and alternatives to elimination diets. on automatic orders of eligible items on a schedule that is convenient for you. Its a veterinary probiotic supplement for the dietary management of dog, puppies, cats or kittens with diarrhea. And while thats great for busy mornings at home or when travelling, your digestive system also benefits. PURINA PRO PLAN VETERINARY DIETS EL Elemental Canine Formula Dry Dog Food, 8-lb bag - Chewy.com We're sorry, this item isn't available any more. Borrelli O, Cordischi L, Cirulli M, et al. according to instructions on the label.